Human tolerogenic DC-10: perspectives for clinical applications
نویسندگان
چکیده
منابع مشابه
Human tolerogenic DC-10: perspectives for clinical applications
Dendritic cells (DCs) are critically involved in inducing either immunity or tolerance. During the last decades efforts have been devoted to the development of ad hoc methods to manipulate DCs in vitro to enhance or stabilize their tolerogenic properties. Addition of IL-10 during monocyte-derived DC differentiation allows the induction of DC-10, a subset of human tolerogenic DCs characterized b...
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Human leukocyte antigen (HLA)-G is a non-classical HLA class I molecule with known immune-modulatory functions. Our group identified a subset of human dendritic cells, named DC-10, that induce adaptive interleukin-10-producing T regulatory type 1 (Tr1) cells via the interleukin-10-dependent HLA-G/ILT4 pathway. In this study we aimed at defining the role of HLA-G in DC-10-mediated Tr1 cell diffe...
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ژورنال
عنوان ژورنال: Transplantation Research
سال: 2012
ISSN: 2047-1440
DOI: 10.1186/2047-1440-1-14